Small molecules & peptides
Desmethyl-MPC-6827
Precursor for [¹¹C]MPC-6827
4-[Methyl(2-methyl-4-quinazolinyl)amino]phenol; N-(4-Hydroxyphenyl)-N-(2-methylquinazolin-4-yl)methylamine; MPI-04406267
Phenol, 4-[methyl(2-methyl-4-quinazolinyl)amino]-
Quality
Research Chemical
Characteristics
Molar mass 265.31
CAS RN [827031-26-5]
Purity ≥ 95 %
- brownish to off-white solid
- soluble in dimethyl sulfoxide
Certificates
CoA: appearance, ¹H-and ¹³C-NMR spectra
Literature
Kumar, J. S. D. et al. Radiosynthesis and in vivo evaluation of [¹¹C]MPC-6827, the first brain penetrant microtubule PET ligand J. Med. Chem. 2018.
Kumar J. S. D, Mann J. J. Radiolabeled microtubule imaging agents and uses thereof. 2017, US patent No. 62/578,903.
Sirisoma, N. et al. Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration J. Med. Chem. 2009 52 (8), 2341–2351.
Kasibhatla, S. et al. A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps. Cancer Research 2007, 67 (12), 5865–5871.
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| Product | Product No. | Filling amount | Quantity | ||
|---|---|---|---|---|---|
| /products/small-molecules-and-peptides/chemical/1fc8dc3f-2f41-4dbe-8546-676c462ce0ea | Precursor | Product No.: 2446 |
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